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KMID : 0617320010100010154
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Journal of Pharmacetical Sceiences Ewha Womans University
2001 Volume.10 No. 1 p.154 ~ p.157
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SYNTHESIS OF NOVEL D- AND L-3´-DEOXY-3´-C- HYDROXYMETHYL NUCLEOSIDE WITH EXOCYCLIC METHYLENE AS POTENTIAL RIBONUCLEOTIDE REDUCTASE INHIBITOR
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Chun, Moon Woo
Kim, Myung jung/Jo, Un Hee/Kim, Joong Hyup/Kim, Hee-Doo/Jeong, Lak Shin
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Abstract
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D- and L-3´-C-hydroxymethyl thymidine substituted with exocyclic methylene at 2´-position were synthesized, starting from D-and L-xylose as potential ribonucleotide reductase inhibbitor, respectively, but they were found to be inactive against several tumor cell lines.
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